Action and mechanism
Non-absorbable antacid. Aluminum and magnesium derivative. It works by neutralizing hydrochloric acid in the stomach, increasing gastric ph, which also reduces the formation and activity of pepsin. In addition, it adsorbs pepsin that has formed and adsorbs and neutralizes bile acids when they reflux into the stomach.
Pharmacokinetics
Absorption: the absorption of aluminum and magnesium cations is minimal from a standard dose of antacid. Only the portion corresponding to the soluble compounds formed and whose excess has not precipitated in the intestine is absorbed.
Elimination: unabsorbed magnesium and aluminum are mostly eliminated in the feces as insoluble salts. The absorbed portion minimal is eliminated in the urine.
Renal insufficiency: in cases of renal insufficiency, a decrease in the elimination of magnesium and aluminum could occur, with the consequent risk of hypermagnesemia and hypophosphatemia. Instructions
Symptomatic treatment of processes that involve gastric hyperacidity , such as gastritis , dyspepsia , peptic ulcer , gastroesophageal reflux disease or hiatal hernia .
Posology
Adults, oral:
* Chewable tablets: 2 tablets 1 g 8 h.
* Oral suspension: 7.5 Ml 1 g 8 h.
* Envelopes: 1 envelope 1.5 G 8 hours.
Administer preferably 0.5-1 Hour after meals. In certain cases, an additional dose may be necessary before bedtime. Maximum dose 8 g 24 h.
Children and adolescents under 18 years of age, oral:
* Adolescents 12 years: same as ...
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