Action and mechanism hypnotic . Valerian has been shown in animal and human studies to induce and improve sleep. Although not known for certain, the effects appear to be due to valerenic acid and valepotriates. The mechanism of action of these compounds is also not fully understood. It is speculated that they may decrease the degradation of gamma-aminobutyric acid gaba , increase its release into the synaptic spaces, and decrease its reuptake. In addition, large amounts of glutamine have been detected in valerian, which could be taken up by neurons and transformed into gamma-aminobutyric acid. Furthermore, in vitro studies have shown that hydroxypinoresinol is capable of binding to the benzodiazepine receptor.
Antispasmodic . Valerian produces relaxation of smooth muscle. The effects could be due to inhibition of calcium channels in the cell or to binding of valepotriates to the muscle fiber itself. Special warnings
Monitoring liver function is recommended in patients with liver failure. Patient advice
It can cause drowsiness, so caution is advised when driving.
It is recommended to take this medicine at least 2 hours before bedtime.
The effectiveness of valerian root is achieved gradually therefore, it is not suitable for treating acute nervous tension or sleep disorders. Contraindications
Hypersensitivity to any component of the medication. Effects on driving valerian can cause drowsiness, so patients should avoid operating dangerous machinery, including auto...
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Action and mechanism hypnotic . Valerian has been shown in animal and human studies to induce and improve sleep. Although not known for certain, the
